Medical Lasers

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Fig. 5. In vivo rat skin reactions after argon plasma and nitrogen plasma treatments. (A, B) The in vivo male Sprague-Dawley rat skin was treated with 15 passes of microwave-generated, atmospheric-pressure, non-thermal argon plasma using a plasma generator (PladuoTM; Shenb Co., Ltd., Seoul, Korea) at the energy setting of 0.8 J and a distance setting of 5 mm. Multiple passes of argon plasma treatment generates remarkable vacuolar changes in the entire epidermis and mild thermal tissue reactions with inflammatory cell infiltration in the upper dermis. Microscopic photographs were taken (A) immediately and (B) 1 day after argon plasma treatment. (C, D) In vivo rat skin treated with five passes of microwave-generated, atmospheric-pressure, non-thermal nitrogen plasma treatment at the energy setting of 1.5 J and a distance setting of 5 mm. Nitrogen plasma-induced thermal coagulation was found throughout the entire epidermis with microscopic features of partial re-epithelization at Day 1 and complete re-epithelization at Day 5. Hematoxylin and eosin stain, original magnification ×400.
Medical Lasers; Engineering, Basic Research, and Clinical Application 2020;9:12~24 https://doi.org/10.25289/ML.2020.9.1.12
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