Medical Lasers

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Table 2

Clinical studies evaluated efficacy of phototherapy in allergic rhinitis patients

Study design Laser Irradiation condition Measured parameters References
Randomized, controlled trial (N=49) Rhinolight (5% UV-B, 25% UV-A, 70% visible light) Intranasal, 3 times/week for 3 weeks Clinical AR symptoms (TNSS)Nasal lavage samples: number of eosinophils, eosinophilc cationic protein level, IL-5 Koreck et al. 13
Randomized, controlled trial (N=62) Rhinolight Intranasal, 3 times/week for 2 weeks Clinical AR symptoms, quality of life score (TNSS, GSS, RQLQ) Soheila et al. 24
Randomized, controlled trial (N=77) Rhinolight Intranasal, 3 times/week for 2 weeks Clinical AR symptoms, quality of life score (TNSS, RQLQ) Nasal resistance Albu et al. 25
Case series (N=17) PUVA Intranasal 4 times/week for 3 weeks Clinical AR symptoms (TNSS) Allergen-induced wheal formation in the SPT reaction Csoma et al. 26
Case series (N=18) 308 nm XeCl UVB laser Intranasal 2 times/week for 2 weeks Clinical AR symptoms (TNSS) Allergen-induced wheal formation in the SPT reaction Csoma et al. 29
Randomized, controlled trial (N=101) SN-206 (652/940 nm wavelength) Intranasal 3 times/day for 2 weeks Symptom scores (sneezing/itching) ECP levels Nasal flow readings Emberlin et al. 30
Randomized, controlled trial (N=79) Bionase unit (660±5 nm wavelength) Intranasal, 3 times/day for 2 weeks Improvement of AR symptoms (nasal obstruction, rhinorrhea, edema of middle turbinate, nasal itching, headache, cough (postnasal drip)) Neuman et al. 31

AR, allergic rhinitis; TNSS, total nasal symptom score; GSS, global severity score; RQLQ, rhinoconjunctivitis quality of life questionnaire; PUVA, photochemotherapy with 8-methoxypsoralen (8-MOP) plus UVA light; SPT, skin prick test; ECP, eosinophilic cationic protein.

Medical Lasers; Engineering, Basic Research, and Clinical Application 2020;9:95~102 https://doi.org/10.25289/ML.2020.9.2.95
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