Medical Lasers

pISSN 2287-8300
eISSN 2288-0224

Table 1

In vitro studies with animal models evaluated effectiveness of phototherapy on allergic rhinitis/asthma

Disease Animal model Laser specifications Irradiation condition Measured parameters References
AR Ovabumin induced AR mouse (Balb/c) 658 nm wavelength, 30 mW power output 1 J/cm2, 2 J/cm2, continuous irradiation - Total IgE, IL-4- Thymus and activation regulated chemokine Choi et al. 15
Ovalbumin induced AR mouse (Balb/c) 650 nm wavelength, 5 mW power output 15 min /day, continuous irradiation with straight/diffusion type fibers - Allergic symptoms- Serum immunoglobulin levels- Eosinophilic infiltration in the nasal mucosa and cervical lymph nodes- Systemic/local cytokine levels Bae et al. 19
Allergic asthma Ovalbumin induced allergic asthma rats 810 nm wavelength, 80 mW power output 8 J/cm2 for 21days - Pathological damage/airway inflammation- Total numbers of cells/eosinophils in BAL fluid- Serum immunoglobulin/cytokine levels Wang et al. 20
HDM induced allergic asthma mouse 660 nm wavelength, 100 mW power output 1, 3, 5, and 7.5 J - Pathological airway inflammation - Total numbers of cells in BAL fluid (neutrophils, eosinophils, and T lymphocytes)- Serum cytokine levels Rigonato-Oliveira et al. 21

AR, allergic rhinitis; BAL, bronchoalveolar lavage; HDM, house dust mite; IL, interleukin.

Medical Lasers; Engineering, Basic Research, and Clinical Application 2020;9:95~102
© Medical Lasers