Medical Lasers

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Fig. 5. Immunohistochemistry for COL1A1 in skin of porcine treated or untreated with 630-and 850-nm LED and microcurrent. Upregulated COL1A1 expression at protein levels strongly correlates with simultaneously 630-nm and 850-nm LED and microcurrent application. (A) Representative immunohistochemical photo-image (upper) and (B) graphical quantification (lower) of COL1A1 protein expression in each group. COL1A1 is highly expressed in 630-nm and 850-nm LED only and microcurrent only group compared to combined treatment. Statistically significant variations were indicated as *p < 0.05, **p < 0.01, ***p < 0.001 (vs Control), #p < 0.05 (vs 2 weeks).
Medical Lasers; Engineering, Basic Research, and Clinical Application 2021;10:96~105
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