Medical Lasers

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Fig. 3. mRNA transcription of extracellular matrix-related molecules were analyzed in photoaged, ex vivo human skin after fractional microneedle radiofrequency (FMRF) treatment and application of the antioxidant formulation. (A) Expression of type III collagen (COL3A1) was statistically significantly increased after a single session of FMRF treatment. (B) FMRF treatment induced a statistically significant increase in transforming growth factor-beta (TGF-ꞵ) expression. (C) Fibroblast growth factor (FGF2) expression increased upon FMRF treatment and increased further upon application of the antioxidant formulation. Data are indicated as mean ± standard error. Differences between groups were compared using an unpaired t-test. ##indicates a significant difference (p < 0.01) between two groups; *(p < 0.05) and **(p < 0.01) indicate significant differences from the positive control. CEF, combination antioxidant formulation; COL3A1, type III collagen; FGF2, fibroblast growth factor 2; FMRF, fractional microneedle radiofrequency; TGF-β, transforming growth factor-beta.
Medical Lasers; Engineering, Basic Research, and Clinical Application 2021;10:161~169 https://doi.org/10.25289/ML.2021.10.3.161
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