Medical Lasers; Engineering, Basic Research, and Clinical Application 2018; 7(1): 1-5  
Review of the Current State of Medical Plasma Technology and its Potential Applications
Ik Jun Moon, Chong Hyun Won
Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea
Correspondence to: Chong Hyun Won, Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88, Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Korea, Tel.: +82-2-3010-3460, Fax: +82-2-486-7831, E-mail: drwon@amc.seoul.kr
Received: April 26, 2018; Accepted: April 27, 2018; Published online: June 30, 2018.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Plasma technology is entering a new chapter through medical use. Medical devices based on plasma technology have recently been tested for the biochemical effects of plasma on cells and tissues. The implementation of plasma technology in medicine was made possible by the introduction of non-thermal, cold plasma emitted at atmospheric pressure. To date, the putative biological effects of plasma include decontamination, disinfection, tooth bleaching and accelerated wound healing. In addition, cold plasma treatment has some potential as a novel cancer therapeutic. Plasma is currently believed to exert its diverse effects mainly by regulating both intra-and extracellular oxidation-reduction reactions as a result of the generation of reactive oxygen and nitrogen species. Interestingly, the biological effects of plasma exhibited hormesis, which is a biphasic response depending on the degree or amount of exposure. Ongoing investigations focus largely on elucidating how the modulation of oxidation-reduction by plasma affects the behavior of cells and helps determine the optimal treatment parameters maximizing the favorable effects of cold plasma. Although accumulating evidence indicates the role of cold plasma as the next-generation therapeutic in various medical fields, more detailed characterization of the biomolecular effects of plasma appears to be the next critical step, along with clinical studies designed to validate its clinical efficacy and safety.
Keywords: Plasma medicine; Non-thermal plasma; Reactive oxygen and nitrogen species; Wound healing; Oxidation-reduction


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