Med Laser  
Facial Rejuvenating Effects of Mesotherapy Using a New Polycomponent Formulation
Gyu Sik Jung1, Jeung Ryeol Eom1, Hyeon Jun Jeon1, Seung Gyun Chu1, Eugene Oh2, Jae Woong Lee3
1Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, Daegu, Korea
2Department of Chemical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, Korea
3Giho Cultural Heritage Research Center, Anseong, Korea
Correspondence to: Gyu Sik Jung
Department of Plastic and Reconstructive Surgery, School of Medicine, Kyungpook National University, 130 Dongdeok-ro, Jung-gu, Daegu 41944, Korea
Tel.: +82-53-200-5685
Fax: +82-53-425-3879
E-mail: jksheart@naver.com
Received: July 28, 2018; Accepted: August 20, 2018; Published online: September 27, 2018.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background and Objectives Facial rejuvenation via mesotherapy using a new polycomponent formulation was employed to improve skin texture. In this study, we evaluated the rejuvenating effects of a new polycomponent formulation through mesotherapy using a microneedle therapy system (MTS).
Materials and Methods Twenty patients underwent a series of facial procedures, including three sessions performed at 2-week intervals and two sessions at 4-week intervals. Subsequently, 3 mL of new polycomponent formulation was applied to the entire face and MTS was used. Patient satisfaction scoring was conducted by three plastic surgeons who evaluated the improvement of fine wrinkles, skin tightness, hydration, and sweat pore size. In addition, photographs of the patients were taken at each visit and 2 months after the last treatment session.
Results The patients were satisfied with the therapeutic outcomes. The scores of the surgeons for the improvement of fine wrinkles, skin tightness, hydration, and sweat pore size were high.
Conclusion Minimally invasive mesotherapy using a new polycomponent formulation can improve the clinical appearance of facial skin. However, a larger-scale and well-controlled investigation of the clinical efficacy and safety of this technique is needed to confirm these findings.
Keywords: Mesotherapy; Microneedle Therapy System; Facial Rejuvenation; Aging; Fibroblasts


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