Medical Lasers; Engineering, Basic Research, and Clinical Application  
Polydeoxyribonucleotide and Microlens Array-type, Nanosecond-domain Neodymium:Yttrium-aluminum-garnet Laser Treatment for Scars from Costal Cartilage Harvest Surgery: Case Series of 9 Patients
Keun Jae Ahn1, Do Yeon Kim2, Gwahn-Woo Cheon3, Hyun Jun Park4, Tae Hwan Ahn5
1Department of Science Education, Jeju National University, Jeju, Korea
2R&D Center, BNV Biolab, Seoul, Korea
3Maylin Clinic (Pangyo), Seongnam, Korea
4Maylin Clinic (Apgujeong), Seoul, Korea
5Fresh Facial Aesthetic Surgery and ENT Clinic, Seoul, Korea
Correspondence to: Tae Hwan Ahn
Fresh Facial Aesthetic Surgery and ENT Clinic, Kukdong Starclass building 2F-3F, 2615 Nambusoonhwan-ro, Gangnam-gu, Seoul 06267, Korea
Tel.: +82-2-575-2033
Fax: +82-2-575-3822
Received: May 17, 2021; Accepted: May 24, 2021; Published online: June 4, 2021.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

Background and Objectives
Surgery for harvesting costal cartilage is often required for revision septorhinoplasty due to a lack of septal cartilage in patients with a severely contracted nose, and postoperative scarring on the anterolateral rib cage commonly requires additional treatment. This study aimed to evaluate the therapeutic efficacy and safety of combined polydeoxy-ribonucleotide (PDRN) and microlens array (MLA)-type nanosecond-domain neodymium (Nd):yttrium-aluminum-garnet (YAG) laser treatment for postoperative scars after costal cartilage harvest surgery.
Materials and Methods
Nine Korean patients with scars after costal cartilage harvest surgery treated with PDRN injections and MLA-type Nd:YAG laser treatments were retrospectively reviewed.
Most of the scar lesions exhibited clinical improvement at 2 weeks after PDRN and MLA-type nanosecond-domain laser treatments, and the lesions further improved after adding more treatment sessions. The median Vancouver Scar Scale (VSS) score decreased from 6 (inter-quartile range [IQR]: 6-7) before combined intralesional PDRN injection and MLA-type, nanosecond-domain Nd:YAG laser treatments to 3 (IQR: 2-4) thereafter. Patient satisfaction after the combination treatments was rated as satisfactory. None of our patients reported major adverse events.
This case series study demonstrated that combined PDRN and MLA-type, nanosecond-domain Nd:YAG laser treatments are effective and safe for treating scars from costal cartilage harvest surgery.
Keywords: Scar; Costal cartilage harvest surgery; Polydeoxyribonucleotide; Neodymium:yttrium-aluminum-garnet laser; Rhinoplasty; Septoplasty

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