Medical Lasers; Engineering, Basic Research, and Clinical Application  
Decade Long Survey of Low-level Laser Therapy/Photobiomodulation (LLLT/PBM) Therapy for Oral Mucositis Treatment
Hyun Seok Ryu1,2, Celine Abueva1, Phil-Sang Chung1,3, Seung Hoon Woo1,3
1Beckman Laser Institute Korea, Dankook University, Cheonan, Korea
2Interdisciplinary Program for Medical Laser, Dankook University, Cheonan, Korea
3Department of Otorhinolaryngology Head and Neck Surgery, Dankook University School of Medicine, Cheonan, Korea
Correspondence to: Seung Hoon Woo
Department of Otorhinolaryngology Head and Neck Surgery, Dankook University School of Medicine, 201 Manghyang-ro, Dongnam-gu, Cheonan 31116, Korea
Tel.: +82-41-550-1781
Fax: +82-41-550-7837
E-mail: lesaby@hanmail.net
Received: April 5, 2021; Accepted: June 7, 2021; Published online: July 29, 2021.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

Abstract
Low-level laser therapy or photobiomodulation (LLLT/PBM) therapy has been widely applied to enhance and accelerate the recovery of oral mucositis. This study investigates the documented effect of LLLT on oral mucositis caused by chemotherapy. This review appraises 6 animal studies and 12 clinical studies published in the Pubmed database during the past 10 years, related to the application of LLLT for the treatment of mucositis. Despite varied parameters and diverse conditions, the assessed articles indicate that application of LLLT on oral mucositis using near-infrared wavelengths is prophylactic, reduces pain, and enables a rapid recovery. Various combined treatments were also identified among the published papers, which further establishes the efficacy of LLLT as a viable treatment.
Keywords: Oral mucositis; Low-level laser therapy; Photobiomodulation therapy; Chemotherapy


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