Medical Lasers; Engineering, Basic Research, and Clinical Application  
Synergistic Effects of Cisplatin-epigel and Interstitial KTP Laser Treatment on a Xenografted Squamous Cell Carcinoma
Min Seok Song, Sang Joon Lee, Phil Sang Chung, Seung Hoon Woo
Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Korea
Correspondence to: Phil Sang Chung
Department of Otolaryngology-Head and Neck Surgery, Dankook University College of Medicine, 201 Manghyang-ro, Dongnam-gu, Cheonan 31116, Korea
Tel.: +82-41-550-1781
Fax: +82-41-550-7837
E-mail: pschung@dankook.ac.kr
Received: May 20, 2021; Accepted: June 24, 2021; Published online: August 2, 2021.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

Abstract
Background and Objectives
Cisplatin is an important chemotherapy drug for the treatment of head and neck cancer. Interstitial laser treatment (ILT) has cosmetic utility and is very important for maintaining the function of the head and neck after cancer treatment. This study examined the synergistic effects of locally injected cisplatin-epigel and high fever induced by an interstitial potassium titanyl phosphate (KTP) laser treatment on a xenografted human Heinz squamous cell carcinoma.
Materials and Methods
SNU-1041 (107 cells/0.1 ml) cells were xenografted into the back of nude mice by subcutaneous injection. The ILT group (n = 10) was treated with a KTP laser (1 J/mm3) through a cylindrical diffuser tip inserted into the tumor, monitoring the temperature at 43-45°C. In the combined treat-ment group (n = 10), local hyperthermia was induced by intratumoral injection of 100-200 µg of cisplatin into a collagen-based gel carrier (cisplatin-epigel), which was released slowly four hours before ILT. After four weeks of follow-up, the treated tumors were evaluated for tumor remission and volume change.
Results
Eight (80%) of the combined group showed complete tumor remission at the four-week follow-up, whereas only three (30%) of the ILT group showed remission (30%) (p < 0.01).
Conclusion
The current study has shown the synergistic effects of a local cisplatin injection and high fever from ILT on a xenografted human Heinz squamous cell carcinoma.
Keywords: Interstitial laser therapy; Cisplatin-epigel; Squamous cell carcinoma


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