Medical Lasers; Engineering, Basic Research, and Clinical Application 2021; 10(3): 185-188  https://doi.org/10.25289/ML.2021.10.3.185
Photodynamic Therapy Combined with 1064-nm Nd:YAG Laser Therapy and Topical Efinaconazole for Refractory Onychomycosis: Case Series
Jae Wan Park, Young Gue Koh, Seong Jun Seo, Kui Young Park
Department of Dermatology, Chung-Ang University Hospital, Seoul, Korea
Correspondence to: Kui Young Park
Department of Dermatology, Chung-Ang University Hospital, 102 Heukseok-ro, Dongjak-gu, Seoul 06973, Korea
Tel.: +82-2-6299-1525
Fax: +82-2-6299-1718
E-mail: kyky@caumc.or.kr
Received: August 5, 2021; Accepted: September 7, 2021; Published online: September 14, 2021.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Onychomycosis is the most common disease of the nail, with a worldwide prevalence of 5.5%. It causes local pain, paresthesia, and cosmetic problems and decreases the patients’ quality of life. Conventional treatments include the administration of topical and systemic agents. However, factors such as subungual hyperkeratosis and biofilm formation may affect the efficacy of these treatments. Moreover, side effects associated with systemic agents are a major concern for patients. Therefore, various novel treatments are being developed; among them, photodynamic therapy (PDT) and Nd:YAG laser are promising, and several studies have demonstrated the efficacy and safety of PDT and laser therapy. Here, we report the efficacy and tolerability of PDT combined with 1064-nm Nd:YAG laser therapy and topical efinaconazole for the treatment of three patients with refractory onychomycosis.
Keywords: Nd:YAG laser; Onychomycosis; Photodynamic therapy


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