Med Lasers  
A review on biomimetic models based on microfluidic devices for drug research
Hwee Hyon Seo1, Celine Abueva2,3, So Young Park2, Andrew Padalhin2,4, Hyun Seok Ryu2,4, Seung Hyeon Yoo1, Hin Kei Kim1, Phil-Sang Chung5, Seung Hoon Woo5
1School of Medical Laser, Dankook University, Cheonan, Republic of Korea
2Beckman Laser Institute Korea, Cheonan, Republic of Korea
3Medical Laser Research Center, Dankook University, Cheonan, Republic of Korea
4Dankook Institute of Medicine and Optics, Dankook University College of Medicine, Cheonan, Republic of Korea
5Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Republic of Korea
Correspondence to: Seung Hoon Woo
E-mail: lesaby@naver.com
ORCID: https://orcid.org/0000-0001-7560-1140
Received: November 24, 2023; Accepted: December 14, 2023; Published online: January 10, 2024.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Microfluidic devices are widely used in biology for disease diagnosis, organ modeling, cancer and pathogen detection. In this review, we explored how microfluidic devices have been utilized in biomimetic modeling and drug research over the past 5 years by examining published papers which were sourced through a search in the PubMed database. These devices have been custom made for various experimental purposes and have demonstrated outstanding performance and reproducibility in biomimetic modeling and drug research. Most of the reviewed papers were on the treatment of cancers, especially brain cancers. These devices have shown high reproducibility in mimicking structures such as the cell barriers, and they have demonstrated their potential as effective tools in metabolic transfer and cancer metastasis research. These devices enable the real-time observation of drug screening, and provide high-quality results in terms of time and cost efficiency. In drug synthesis, these devices have demonstrated excellent performance in nanoparticle synthesis, encapsulation, and size control.
Keywords: Microfluidics; Biomimetics; Drug screening assays; Antitumor; Nanoparticles


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