Med Lasers  
Utilizing a high power light-emitting diode to induce apoptosis of uterine carcinosarcoma (malignant mixed mullerian tumor) cells through a bi-phasic effect
Gil Jae Jung1, Su Jin Lee1, Yun Dan Kang1, Seung Hoon Woo2, Jong Soo Kim1
1Department of Obstetrics and Gynecology, Dankook University College of Medicine, Cheonan, Republic of Korea
2Department of Otorhinolaryngology-Head and Neck Surgery, Dankook University College of Medicine, Cheonan, Republic of Korea
Correspondence to: Jong Soo Kim
E-mail: soo8541@hanmail.net
ORCID: https://orcid.org/0000-0002-1607-2282
Received: June 10, 2024; Accepted: July 15, 2024; Published online: August 8, 2024.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
Background: Malignant mixed mullerian tumor (MMMT), a carcinoma of the uterus, is a bi-phasic tumor composed of malignant epithelial and mesenchymal components. The treatment of MMMT remains a challenge despite advances in technology. This study is a preliminary investigation of the potential use of high power lightemitting diode (HPLED) modules as an alternative to laser therapy for cancer treatment.
Methods: This study used 656 and 850 nm HPLEDs at 50 mW power output within a non-thermal range duration. The viability and proliferation of the cells were analyzed after irradiation with the HPLEDs.
Results: A significant reduction in cancer cell viability was observed after irradiation with either the 656 or 850 nm HPLED.
Conclusion: This study shows the potential use of HPLEDs for cancer treatment.
Keywords: Uterine cancer; Malignant mixed tumor

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