Med Lasers  
Combination of polycaprolactone-based topical formulation and nonablative cold atmospheric plasma in the treatment of rosacea: case reports
Nark-Kyoung Rho1, Hyun-Jo Kim2
1Leaders Aesthetic Laser and Cosmetic Surgery Center, Seoul, Republic of Korea
2CNP Skin Clinic, Asan, Republic of Korea
Correspondence to: Nark-Kyoung Rho
E-mail: rhonark@hanmail.net
ORCID: https://orcid.org/0000-0003-0341-3460
Received: January 8, 2025; Accepted: February 3, 2025; Published online: February 17, 2025.
© Korean Society for Laser Medicine and Surgery. All rights reserved.

This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
Abstract
This report describes two cases of patients with rosacea treated with a polycaprolactone (PCL)-based topical formulation combined with nonablative cold atmospheric plasma (CAP). Both patients, two Korean females aged 32 and 47 years, exhibited substantial improvement in their symptoms following the combined therapy. The CAP-assisted topical PCL emulsion therapy effectively diminished facial erythema, telangiectasia, and the inflammatory papules of rosacea without any significant adverse events. The report suggests that this novel therapeutic approach may represent a promising alternative to laser therapy for managing rosacea, underscoring the need for further research to elucidate its long-term efficacy and safety.
Keywords: Polymers; Plasma gases; Polycaprolactone; Rosacea

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